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Sysmex Corporation
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Sysmex Corporation
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Image Search Results
Journal: Human Mutation
Article Title: Weaver Syndrome‐Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro
doi: 10.1002/humu.22946
Figure Lengend Snippet: Weaver syndrome mutants are impaired in their histone methyltransferase activity in vitro . Histone methyltransferase reactions were performed using 2 μg purified core histones and 0.67 μM 3 H‐S‐adenosyl‐methionine ( 3 H‐SAM). Each reaction was incubated with 250 ng of either wild‐type (WT) or a mutant HMTase complex (or no enzyme controls). Histone methyltransferase activity was measured based on the incorporation of 3 H‐labeled methyl groups, represented in scintillation counts per minute. Counts were normalized by subtracting background counts (i.e., no enzyme) from the total counts. A : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for each complex: EZH2 WT • , p.(Phe672Ile) × , p.(Pro132Ser) ★ , p.(Tyr153del) △, p.(His694Tyr) ▽, p.(Glu745Lys) ▴, p.(Ala682Thr) ▾, p.(Arg684Cys) ▪, p.(Tyr133Cys) □, and p.(Asp185His) ◇. Error bars represent standard deviation (SD) within the groups “EZH2 WT” and “EZH2 mutants.” Unpaired t‐test showed statistically significant difference between the two groups (P value < 0.0001). B : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for the positive control EZH2 WT, the negative control EZH2 (p.Phe672Ile), and the mutant complex with activity closest to WT, namely, EZH2 (p.Pro132Ser). Error bars represent SD of four independent replicates for the controls, and three independent replicates for the mutant EZH2 (p.Pro132Ser). One‐way ANOVA showed statistically significant difference between all groups (overall P value < 0.0001; P values between WT and p.(Phe672Ile), between p.(Phe672Ile) and p.(Pro132Ser), and between WT and p.(Pro132Ser) were all <0.05).
Article Snippet: To test our hypothesis, we designed
Techniques: Activity Assay, In Vitro, Purification, Incubation, Mutagenesis, Labeling, Standard Deviation, Positive Control, Negative Control
Journal: Practical Laboratory Medicine
Article Title: Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and Sysmex XN-9100™ hematology analyzers
doi: 10.1016/j.plabm.2025.e00453
Figure Lengend Snippet: Regression analysis in the newborn population. Results of the method comparison study between the Sight OLO® and the Sysmex XN™ hematology analyzers. Graphs indicate Pearson correlation, slope and intercept for the main parameters. WBC: White Blood Cells, RBC: Red Blood Cells, PLT: Platelets, HGB: Hemoglobin, NEUT: Neutrophils, LYMPHO: Lymphocytes, MONO: Monocytes, EOS: Eosinophils, BASO: Basophils.
Article Snippet: Flags of the
Techniques: Comparison
Journal: Practical Laboratory Medicine
Article Title: Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and Sysmex XN-9100™ hematology analyzers
doi: 10.1016/j.plabm.2025.e00453
Figure Lengend Snippet: Bias plot in the newborn population. Bland Altman of the results of a method comparison study between the Sight OLO® and the Sysmex XN™ hematology analyzers for the main measurements in the newborn population. WBC: White Blood Cells, RBC: Red Blood Cells, PLT: Platelets, HGB: Hemoglobin, NEUT: Neutrophils, LYMPHO: Lymphocytes, MONO: Monocytes, EOS: Eosinophils, BASO: Basophils.
Article Snippet: Flags of the
Techniques: Comparison
Journal: Practical Laboratory Medicine
Article Title: Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and Sysmex XN-9100™ hematology analyzers
doi: 10.1016/j.plabm.2025.e00453
Figure Lengend Snippet: Bias plot in the adult population. Bland Altman of the results of method comparison study between the Sight OLO® and the Sysmex XN™ hematology analyzers for the main measurands in the adult population. WBC: White Blood Cells, RBC: Red Blood Cells, PLT: Platelets, HGB: Hemoglobin, NEUT: Neutrophils, LYMPHO: Lymphocytes, MONO: Monocytes, EOS: Eosinophils, BASO: Basophils.
Article Snippet: Flags of the
Techniques: Comparison
Journal: Practical Laboratory Medicine
Article Title: Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and Sysmex XN-9100™ hematology analyzers
doi: 10.1016/j.plabm.2025.e00453
Figure Lengend Snippet: Instrumental analytical alarms (flags) concordance between Sight OLO® and Sysmex XN™ in the newborn population.
Article Snippet: Flags of the
Techniques:
Journal: Practical Laboratory Medicine
Article Title: Complete blood count in neonatal Intensive care Unit (NICU): Performance comparison between POCT Sight OLO® and Sysmex XN-9100™ hematology analyzers
doi: 10.1016/j.plabm.2025.e00453
Figure Lengend Snippet: Instrumental analytical alarms (flags) concordance between Sight OLO® and Sysmex XN™ in the adult population.
Article Snippet: Flags of the
Techniques: